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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, provided they also have problems with weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle including a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight-loss for people who are obese or are overweight and have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes established that patients had the average weight loss of four years old.1% in contrast to participants who have been given placebos) after a 12- month period, while another study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to lose weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people who go through it one should err along the side of caution and let the FDA do its job and demand some research be done so your public understands the side effects and risks of the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say anything to keep people on their own medications.

Researchers discovered that participants taking this drug for the year, lost excess weight within four weeks and have kept the body weight off through the entire 56 weeks of the study. Contrave is often a combination of the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills has become popular is the fact that since right now there aren't any long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise blood pressure and pulse rate, and mustn't be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure level, as well as by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

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